Noninvasive gene delivery to the Brain

We are currently working on improving the noninvasive gene delivery to the brain through focused-ultrasound BBB opening (FUS-BBBO). Current work will improve cost, safety, and transduction efficiency of the technique. For an example application, see ATAC page.

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Image: Noninvasive gene delivery of an inhibitory DREADD (red). The immunostained red area is a mouse dorsal hippocampus showing pronounced expression of an inhibitory DREADD.